Allergies and The Immune System

Why your allergy medicine will never work!
a woman outside sneezing with a clothespin on her nose

As a practicing pharmacist for over 20 years, every spring and fall, I get asked many times, what is the best medication for seasonal allergies? To which I reply, none of them. No medication will ever truly help your seasonal allergies.

You are going about it all wrong and here is why.

Histamine is not the issue.

Contrary to popular belief, seasonal allergies are not a histamine problem. I know, hard to believe as the options that line the pharmacy shelves are all labels “anti-histamine”.

We have been conditioned to believe that by controlling histamine (with pills, creams, liquids) we are treating the problem. But in reality, we are only scratching the surface.

The Core Reason for Seasonal Allergies

While histamine is certainly a component of seasonal allergies, it is just a small part of the real issue. Your Immune system.

Seasonal allergies to pollen, dust, mold, pet dander and many others is caused by your immune system over-reacting to something harmless.

Reacting in the same way it would to a virus or bacteria recruiting additional immune cells that result in inflammation.

Designing the Ideal Allergy Remedy

The ideal natural allergy remedy would involve a combination of herbs that address histamine and balance your immune system.

All too often, I find that many natural brands overly focus on controlling histamine with combinations of ingredients such vitamin C, bromelain, stinging nettle, quercetin and many more. Worse, many brands, when you look at their labels closely, are almost identical formulas.

These formulas often miss the mark on how to truly help people with allergies.

Immune Support is the Key

The true problem with seasonal allergies is not histamine as we have been trained to think. It is our immune system.

Much like how our body’s immune system responds to viruses, it sometimes undergoes the same response to allergens such as pollen, pet dander, mold and more. For people with seasonal allergies, your immune system has identified it as a foreign entity that must be attacked and removed.

This immune response is a natural reaction and favorable. But sometimes the immune system overreacts and creates unnecessary inflammation by releasing too many inflammatory mediators and recruiting excessive help from the immune system.

The secret to seasonal allergy control is in balancing the immune response. Balancing the immune response in the right way can make all the difference.

Top 5 Herbs for Immune Support for Seasonal Allergies

  • Butterbur

    Acts by stabilizing an important immune cell called the mast cell.

    Mast cells contain a lot of inflammatory medications such as interleukins, prostaglandins, cytokines and histamine.

    Butterbur standardized to petasins has been shown in clinical studies to be very effective at stabilizing the cell membrane and limiting the release of these highly inflammatory chemicals.

  • Apigenin

    Often overlooked but so important in the moderation of the immune response for allergies.

    This ingredient is found in high concentrations in parsley and celery. Its specific action is balancing T helper cells.

    T helper cells are divided between TH1 and Th2. An imbalance in T helper cells can lead to worse allergy symptoms.

    Apigenin restores this balance in your body.

  • Andrographis

    This ayurvedic herb has a long history of showing benefit for immune support.

    Andrographis contains andrographolide which helps support inflammation and has mild astringent properties. Highly standardized andrographis promotes healthy breathing pathways quickly.

  • Rosmarinic Acid

    Derived from the rosemary plant, this ingredient when used in its purest form can have a significant impact on histamine.

    Rosmarinic acid is best used in combination with other herbs when using it for seasonal allergies.

  • Quercetin Dihydrate

    Very beneficial for controlling both histamine formation and release. It also has some benefits for stabilizing mast cells.

    Quercetin alone is not very effective for seasonal allergies but when paired with other immune support ingredients, it can be very effective.

    It is important to know that not all quercetin forms are equal in absorption. Quercetin dihydrate has very good absorption characteristics (up to 80%) in the GI system compared to traditional quercetin which is only 5% absorbed into the body.

Seasonal allergies affect up to 30 million people every year and the number seems to be growing. Many people use medication to help control their allergies but suffer the consequences of side effects. HybridAR Rapid Nasal & Sinus Support is the first natural remedy formulated to work quickly and provide all day benefit. HybridAR is designed to provide rapid benefit in just 20 minutes with all day benefit. It is the only natural remedy that you take once a day.

HybridAR is an ideal remedy because it balances and supports your immune system and also healthy histamine levels. It has helped thousands of people switch off of over-the-counter medications such as Claritin, Allegra and Zyrtec to just using HybridAR Rapid Nasal & Sinus Support.

This season, if you are ready to “Make the Switch” from your allergy medication or looking for a natural remedy that will help you enjoy the outdoors again, try HybridAR. It has helped thousands of customers nationwide and can help you too.

§These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


Dr. Jason DuBois

Founder of Hybrid Remedies

Dr. DuBois is a registered clinical pharmacist, educator and Founder of Hybrid Remedies, a natural supplement research and development company.

He is a graduate of the University of Florida with a Doctorate degree in Pharmacy. Prior to starting Hybrid Remedies, Dr. DuBois was the lead clinical pharmacist at the world-renowned Mayo Clinic specializing in immunology and solid organ transplantation. During his tenure, Dr. DuBois has designed numerous clinical trials and immune protocols and has been a contributing author on several published articles.

With over 20 years of pharmacy experience, Dr. DuBois uses his clinical expertise and knowledge of Eastern and Western medicine to help patients safely integrate natural supplements, prescription, and over-the-counter medications together.